The impact of the gut microbiota on circulating leukocyte levels

We posted our new study on bioRxiv were we compared the impact of the microbiota white blood cells dynamics in patients receiving hematopoietic cell transplantation.

We estimate that microbiota diversity can have a suppressive effect on circulating lymphocytes similar to that of immunosuppressive drugs administered to reduce graft vs host disease. This may help explain previous studies from our MSKCC collaborators that associated microbiota diversity to lower transplant-related mortality. There’s more work to be done for a mechanism linking the microbiota to systemic immunity, of course. But this study stands out because it addresses the problem directly in humans.

We are going to wait a few days before we submit the paper for peer review. We appreciate any comments to improve the paper.

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